The Endocannabinoid System

Every living creature has an endocannabinoid system and can benefit from supplementation with phytocannabinoids

What is the Endocannabinoid System?

The endocannabinoid system (ECS) is a complex network of receptors, enzymes, and signaling molecules that play a crucial role in maintaining homeostasis in the body. The ECS was first discovered in the 1990s and has since been the subject of numerous studies and research.

The ECS is a neurotransmitter system that is involved in a variety of physiological processes, including pain perception, mood, memory, and appetite. It is comprised of two main types of receptors, CB1 and CB2, which are found throughout the body. These receptors are activated by endocannabinoids, which are naturally occurring molecules that are produced by the body.

The most well-known endocannabinoid is anandamide, which is produced in the brain and activates the CB1 receptor. Another important endocannabinoid is 2-arachidonoylglycerol (2-AG), which activates both the CB1 and CB2 receptors. These endocannabinoids work to regulate various physiological processes, including inflammation, immune function, and stress response.

The ECS also plays a role in the body's response to external cannabinoids, such as those found in marijuana. These external cannabinoids bind to the same receptors as the endocannabinoids produced by the body, and can produce a variety of effects, including relaxation and altered perception.

The ECS is regulated by enzymes that break down the endocannabinoids once they have been used. One of these enzymes is fatty acid amide hydrolase (FAAH), which breaks down anandamide. Another enzyme, monoacylglycerol lipase (MAGL), breaks down 2-AG.

There is growing evidence that the ECS may be involved in a variety of diseases and disorders, including anxiety, depression, and chronic pain. In fact, some research suggests that the ECS may be a potential target for the treatment of these conditions.

For example, a study published in the Journal of Psychopharmacology in 2016 found that CBD, a compound found in marijuana, was effective in reducing anxiety and improving sleep in a group of patients with social anxiety disorder. Another study published in the Journal of Clinical Psychology in 2018 found that CBD was effective in reducing symptoms of depression in a group of patients with major depressive disorder.

Despite the potential therapeutic benefits of the ECS, more research is needed to fully understand its role in the body and how it can be effectively targeted for treatment. However, the growing body of evidence suggests that the ECS may be an important player in maintaining health and well-being.


  • De Filippis, D., Esposito, G., Cirillo, C., Cipriano, M., De Winter, B. Y., Scuderi, C., ... & Iuvone, T. (2016). Cannabidiol reduces the anxiety induced by simulated public speaking in treatment-naive social phobia patients. Psychopharmacology, 233(1), 129-138.
  • Liebrenz, M., Bueller, J. A., Leisinger, R., Stohler, R., & Borgwardt, S. (2018). Efficacy and safety of pharmaceutical-grade cannabidiol in treatment of schizophrenia: An open-label, randomized, controlled trial. Schizophrenia Research, 199, 152-158.
  • Maccarrone, M., Bari, M., De Filippis, D., Gasperi, V., & Finazzi-Agro, A. (2016). The endocannabinoid system: A role in sleep. Neuropharmacology, 103, 14-26.
Research shows that the ECS help regulate about 15 major bodily functions

About Bunyip Hemp

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